Acute Spinal Cord Injury (ASCI) Metabolomics Through 1H-NMR Spectroscopy: Metabolic alterations with time & treatment
Alka Singh1, Suruchi Singh2, Saloni Raj1, Ravindra Kumar Garg3, Abbas Ali Mahdi4, Raja Roy2, and Rajeshwar Nath Srivastava1
1Orthopaedic Surgery, King George's Medical University, Lucknow, India, 2Centre of Biomedical Research, Lucknow, India, 3Neurology, King George's Medical University, Lucknow, India, 4Biochemistry, King George's Medical University, Lucknow, India
It
mainly focuses on
finding significant metabolites in serum using 1H NMR based
spectroscopic methods and to study the variation of concentration of these
metabolites during the recovery of the patient ongoing treatment after surgery.
Significant metabolites, namely,
lactate, glycine, acetone and succinate were identified using statistical
methods (ANOVA along with Mann- Whitney U test) and are found to be elevated
during the time of injury. The levels gradually decrease as the patient
recovers in an average period of six months.This is a prospective case-control preliminary study on recovery of the
patient during acute spinal cord injury.
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