Imaging response to 90-yttrium radioembolization with volumetric ADC DWI in patients with metastatic liver cancer
Russell Rockne1, Syed Rahmanuddin1,2, John J. Park2, and Jinha M. Park2
1Dept. of Information Sciences/ Mathamatical Oncology, Beckman Research Institute City of Hope, Duarte, CA, United States, 2Radiology, Helford Clinical Research Hospital | Beckman Research Institute, Duarte, CA, United States
The purpose of this study is to evaluate changes in tumor
volume and mean ADC before and after 90-yttrium (Y90) radioembolization for
patients with metastatic liver cancer. Eighteen patients were identified in a
retrospective study. Volumetric analysis of lesions before and after therapy
showed a consistent increase in ADC (p<0.001), suggesting a decrease in
cellularity. Changes in tumor volume measured on post-gadolinium (PG) T1 MRI were not statistically significant.
Additional MRIs following Y90 treatment should be analyzed with clinical
outcomes to determine whether early changes in ADC following therapy may serve
as an early indicator of response.
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