Abstract #2439

Characterization of HPV positive oropharyngeal tumors using intravoxel incoherent motion DW-MRI before and during radiation therapy

Ramesh Paudyal¹, Praveen Venigalla², Jingao Li^2,3, Nadeem Riaz², Jung Oh Hun¹, David Aramburu Nuñez¹, Vaois Haztglou⁴, Yonggang Lu⁵, Joseph O Deasy¹, Nancy Lee², and Amita Shukla-Dave¹

¹Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ³Radiation Oncology, Jiangxi Cancer Hospital, Nanchang, China, People's Republic of, ⁴Radiology, Memorial Sloan Kettering Cancer, New York, NY, United States, ⁵Radiation Oncology, Washington University, St louis, MO, United States

This study aims to characterize human papillomavirus (HPV) positive (+) oropharyngeal cancer (OPC) using intravoxel incoherent motion (IVIM) DW-MRI performed before and during chemo-radiation therapy. A consensus clustering algorithm based on the hierarchical clustering and Pearson correlation distance was performed using the weekly IVIM DW-MRI metrics of D, f and D*, total tumor volume and delivered radiation dose. It demonstrated the presence of two HPV+ clusters. A trend towards significant increase in D during the pre- and intra-treatment (week 3) IVIM DW-MR data suggested that patients in cluster 2 may benefit with use of less aggressive therapy.

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