Abstract #2450

Hormonal effect on time-dependent diffusion of the breast fibroglandular tissue

Sungheon Gene Kim^1,2, Eric Sigmund^1,2, Melanie Moccaldi^1,2, Thorsten Feiweier³, and Linda Moy^1,2

¹Center for Advanced Imaging Innovation and Research, Radiology, New York University School of Medicine, New York, NY, United States, ²Bernard and Irene Schwartz Center for Biomedical Imaging, Radiology, New York University School of Medicine, New York, NY, United States, ³Siemens Healthcare GmbH, Erlangen, Germany

This study is to investigate the potential of the surface-to-volume ratio obtained from multiple diffusion times to measure mammary duct microstructural changes induced by hormonal variation. Seven premenopausal women were scanned twice using a stimulated-echo diffusion sequence; one in the follicular phase of the menstrual cycle and again in the luteal phase. In 6 out of 7 subjects, the surface-to-volume ratio measured with 69 and 173 ms was significantly reduced in the luteal phase compared to the follicular phase. The length scales obtained in our study are consistent with the duct diameters reported in previous ex-vivo studies.

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