1CancerCare Manitoba, Winnipeg, MB, Canada, 2Chemistry, University of Guam, Mangilao, Guam, 3Chemistry, University of Winnipeg, Winnipeg, MB, Canada, 4Health Sciences Centre, Winnipeg, MB, Canada
We undertook this study to
determine if 1H Magnetic Resonance Spectroscopy (MRS) can provide an
alternate tool for the screening of lung cancer. Metabolic
profiles of sputum and exhaled breath condensate
(EBC) samples were obtained from 15 patients (cancer, n=8 and control, n=7) using
a Bruker Avance 400 MHz NMR spectrometer. Methanol was detected at a significantly
lower concentration in the EBC samples (p<0.05). Absence of glucose and
lower concentration of glycoprotein (p<0.05) were observed in the sputum samples of the
cancer patients. MRS may serve as a screening
tool for lung cancer in high-risk patients but this requires validation in a
larger study.
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