Xinran Zhong1,2, Novena Rangwala1, Steven Raman1, Daniel Margolis1, Holden Wu1,2, and Kyunghyun Sung1,2
1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Physics and Biology in Medicine, University of California, Los Angeles, Los Angeles, CA, United States
A simplified version of the B1+ correction method using an approximation model was proposed for estimation of pharmacokinetic modeling parameters. The proposed method was evaluated in both simulation and in vivo DCE-MRI data, and was applied to DCE-MRI with 63 suspicious lesions from two MRI systems to investigate B1+ induced errors in Ktrans. Significant difference of estimated Ktrans distributions was observed between two systems, showing it's necessary to perform B1+ correction for DCE-MRI analysis between systems.