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Abstract #2515

31P spectroscopic imaging for evaluation of early effects of photodynamic treatment on tumor metabolism

Tom Schreurs1, Sophie Peereboom2, Gustav Strijkers3, Jeanine Prompers1, and Klaas Nicolay1

1Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands, 2Biomedical Engineering, ETH Zürich, Zürich, Switzerland, 3Bioengineering and Physics, Academic Medical Center Amsterdam, Amsterdam, Netherlands

The feasibility of 31P spectroscopic imaging to evaluate effects of photodynamic therapy (PDT) on tumor metabolism was assessed. In PDT, a light-activated drug and local laser irradiation are used to ablate tumors. Spectroscopic imaging was used to visualize ATP and Pi after PDT in a mouse tumor model before, during, and up to 1 day after PDT. Treatment was performed inside the 9.4T scanner. Clear changes in phosphorus metabolite signals were already observed at 20 min after PDT, indicating a rapid decrease in energetic status. Moreover, the potential of spectroscopic imaging to detect spatial heterogeneities in these changes was demonstrated.

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