Noninvasive imaging can improve risk stratification in carotid atherosclerosis. Multi-sequence MRI allows visualization of plaque burden and components, while PET can be used to study inflammation. Combining the two modalities with hybrid PET/MRI in a one-stop shop approach may improve assessment of vulnerable plaque.
The goal of this work was to optimize a 3D multi-sequence carotic PET/MRI protocol including 3D MPRAGE, 3D SPACE pre- and post-contrast, and UTE, using simulations and optimization in healthy volunteers.
Feasibility of the protocol was demonstrated in a patient suffering from carotid atherosclerosis (>70% stenosis).