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Abstract #2576

Structural and functional evaluation (SaFE)-MRI of peripheral artery disease (PAD) using 3D double-echo steady-state and time-resolved velocimetry

Michael Langham1, Benoit Desjardins1, Erin Englund1, Emile R Mohler, III2, Thomas Floyd3, Jamal J Derakshan1, and Felix W Wehrli1

1Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, 2Department of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Department of Anesthesiology, SUNY Stony Brook, Stony Brook, NY, United States

An alternative unenhanced structural and functional evaluation (SaFE-MRI) MRI is proposed and described for assessing peripheral artery disease (PAD). The SaFE-MRI protocol interleaves 3D double-echo steady-state (DESS) acquisition and velocity mapping at each station. In SaFE-MRI velocity maps in all major conduit arteries (from abdominal aorta to runoff arteries) serve as a “road map” for locating hemodynamically significant stenoses and gray- and black-blood images are used to grade stenoses and detect vascular calcium. Initial results in patients with PAD agree with the finding from CTA and CE-MRA examinations as well as pressure volume recordings.

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