To
apply DCE-MRI with a biodegradable macromolecular contrast agent in assessment
of the efficacy of targeted ECO/siRNA nanoparticles for silencing HIF-1α
expression for cancer therapy in a mouse colon cancer model. DCE-MRI
non-invasively revealed that the treatment resulted in over 70% reduction in
average tumor blood flow (Fp), permeability-surface area product (PS), and
plasma volume fraction (Vp) in the treatment group as compared to the saline
control group (p < 0.05). The treatment was effective to inhibit tumor
angiogenesis and proliferation.
