Meeting Banner
Abstract #2643

Spatial Overlapping between the Subvolumes with Elevated CBV and with Hypercellularity in Glioblastoma

Hemant Parmar1, Daniel Wahl2, Priyanka Pramanik2, Michelle Kim2, Theodore S Lawrence2, and Yue Cao1,2

1Radiology, University of Michigan, Ann Arbor, MI, United States, 2Radiation Oncology, University of Michigan, Ann Arbor, MI, United States

Standard imaging for glioblastoma relies on post-contrast T1 and T2 FLAIR MRI sequences, which do not accurately reflect tumor biology. Advanced MRI techniques can define biologically relevant and prognostic features of glioblastoma including perfusion-based volumes with high cerebral blood volume (VhCBV) and high b-value diffusion-based hypercellular subvolume (HCV). We defined VhCBV and HCV in 24 patients with glioblastoma prior to undergoing chemoradiation. Surprisingly, there was little overlap between VhCBV and HCV within individual patients, which suggests that these volumes represent distinct aspects of tumor biology and may be independently prognostic. Analysis of failure patterns and prognostic relevance is ongoing.

This abstract and the presentation materials are available to members only; a login is required.

Join Here