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Abstract #2651

Evaluation of the tCho and β-catenin concentration with different molecular biomarkers in breast cancer patients

Khushbu Agarwal1, Gururao Hariprasad2, Komal Rani2, Uma Sharma1, Sandeep Mathur3, Vurthaluru Seenu4, Rajinder Parshad4, and Naranamangalam R Jagannathan1

1Department of NMR and MRI Facility, All India Institute of Medical Sciences, Delhi, India, 2Department of Biophysics, All India Institute of Medical Sciences, New Delhi, India, 3Department of Pathology, All India Institute of Medical Sciences, Delhi, India, 4Department of Surgical Disciplines, All India Institute of Medical Sciences, Delhi, India

We evaluated the correlation of tCho and β-catenin concentrations were correlated with molecular biomarkers (ER, PR and Her2neu) in breast cancer patients. The nuclear β-catenin expression was significantly higher compared to cytosolic expression. A positive correlation between tCho and β-catenin (cytosolic and nuclear fractions) concentrations was seen. The PR- tumors had significantly higher cytosolic β-catenin compared to PR+ tumors. This may be because progesterone acts as an inhibitor of Wnt pathway and thus its absence may lead to increased cytosolic β-catenin in PR- tumors. Results demonstrated role of tCho, β-catenin and progesterone in breast cancer progression.

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