Abstract #2659

In vitro Imaging of Alanine: Application of CEST MRI

Puneet Bagga¹, Srisha Bolledula¹, Harsith Reddy¹, Rishika Reddy¹, Apoorva Sudini¹, Hari Hariharan¹, and Ravinder Reddy¹

¹Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States

Alanine is a highly abundant non-essential amino acid which provides an alternate source of TCA cycle intermediates for energy and cell survival. It has been shown that myc-driven tumors utilize alanine as an energy source over lactate. Currently, alanine can be detected in vivo only by ¹³C NMR spectroscopy. Chemical Exchange Saturation Transfer (CEST) MRI is an imaging technique which exploits the properties of exchangeable protons on the molecule for imaging. In the present study, we have shown the in vitro CEST effect of solution containing alanine.

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