Abstract #2707

4D flow MRI derived energetic biomarkers are abnormal in repaired tetralogy of Fallot patients and may predict deteriorating hemodynamics

Joshua Daniel Robinson^1,2, Cynthia K Rigsby^3,4, Michael Rose³, Susanne Schnell⁴, Alex J Barker⁴, and Michael Markl^4,5

¹Pediatric Cardiology, Ann & Robert H Lurie Children's Hospital, Chicago, IL, United States, ²Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ³Medical Imaging, Ann & Robert H Lurie Children's Hospital, Chicago, IL, United States, ⁴Radiology, Northwestern University Feinberg School of Medicine, Chicago, IL, United States, ⁵McCormick School of Engineering, Northwestern University, Evanston, IL, United States

Tetralogy of Fallot (TOF) is the most common form of cyanotic heart disease. As life expectancy continues to increase, MRI plays a central role in evaluation for post-operative complications and reintervention. Current assessment is based on simplified parameters that measure late expression of underlying physiologic changes, with poor outcome prediction. In this study, we explore quantitative 4D flow metrics which may be important measures of hemodynamic efficiency. We found that energetic metrics are abnormal in TOF compared to healthy controls. While these metrics correlated only modestly with routine measurements of ventricular efficiency, they may represent earlier biomarkers of disease progression.

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