Kofi Deh1, Marjan Zaman1, Padraic O'Malley1, Richard Lee1, Pascal Spincemaille1, and Yi Wang1
Quantitative
susceptibility mapping (QSM) is a recently developed technique for quantifying
magnetic susceptibility and it may be useful in quantifying super-paramagnetic
iron oxide (SPIO) nanoparticles for prostate cancer therapy. Previously,
researchers have been hampered in extending the use of this technique to
cancers outside the brain because of problems such as chemical shift and a large
dynamic susceptibility range. Recently developed algorithms, however, allow us to overcome these problems and we demonstrate their use for
quantifying SPIO in a prostate cancer xenograft model for magnetic
hyperthermia.
