Abstract #2772

Test-retest stability of MTT insensitive CBV leakage correction in DSC-MRI

Atle Bjørnerud^1,2, Magne Mørk Kleppestø¹, Tracy T Batchelor^3,4, Patrick Y Wen⁵, Gregory Sorensen⁶, and Kyrre Eeg Emblem^1,7

¹The Intervention Centre, Oslo University Hospital, Oslo, Norway, ²Dept. of Physics, University of Oslo, Oslo, Norway, ³Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ⁴Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ⁵Center for Neuro-Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, United States, ⁶Siemens Healthcare Health Services, Malvern, MA, United States, ⁷MGH-HST A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States

Contrast agent extravasation is known to be a serious confounder in estimations of cerebral blood volume (CBV) analysis of primary brain tumors using DSC-MRI. We here propose a modified MTT-insensitive method for correction of contrast agent extravasation based on parametric analysis of the tissue impulse response function from a two-compartment kinetic model combined with automated global arterial input function (AIF) approximation. Using DSC-MRI data from 28 patients with recurrent glioblastoma which were scanned twice prior to treatment initiation, we show that the proposed method yields test-retest stability similar to the current reference method, but with the added advantage of reduced MTT sensitivity.

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