Ning Lang1, Hon J. Yu2, Huishu Yuan1, and Min-Ying Su2
1Department of Radiology, Peking University Third Hospital, Beijing, China, People's Republic of, 2Center for Functional Onco-Imaging, Department of Radiological Sciences, University of California, Irvine, CA, United States
A
retrospective DCE-MRI of 76 patients with different metastatic cancers in the
spine (35 lung, 11 thyroid, 12 breast, 7 prostate, 7 liver and 4 kidney) were studied.
Three heuristic parameters: the maximum and steepest wash-in signal enhancement
ratio and the wash-out slope were measured. Two-compartmental pharmacokinetic
analysis was performed to obtain Ktrans and kep. The maximum and wash-in SE
ratio were highly correlated with Ktrans; and the wash-out slope was highly correlated
with kep. The lung cancer had the widest variation, the breast cancer had the
highest wash-in SE ratio, and the thyroid cancer had the greatest wash-out
slope.
