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Abstract #2777

DWI and DCE-MRI for imaging diagnosis on vasculogenic mimicry and predicting responses to vascular-disrupting therapy on primary liver cancers in rats

Yewei Liu1,2, Ting Yin1, Yuanbo Feng1, Jie Yu1, Gang Huang2, Jianjun Liu2, Shaoli Song2, Johannes V Swinnen3, Guy Bormans4, Uwe Himmelreich5, Raymond Oyen6, and Yicheng Ni1

1Theragnostic Laboratory, MoSAIC, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium, 2Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Department of Nuclear Medicine, Shanghai, China, People's Republic of, 3Laboratory of Lipid Metabolism and Cancer, Department of Oncology, Faculty of Medicine, KU Leuven, Leuven, Belgium, 4Radiopharmacy, Department of Pharmaceutical and Pharmacological Sciences, Faculty of Medicine, KU Leuven, Leuven, Belgium, 5Biomedical MRI, MoSAIC, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium, 6Radiology, Department of Imaging and Pathology, Faculty of Medicine, KU Leuven, Leuven, Belgium

Vasculogenic mimicry (VM) refers to tumor cells mimicking endothelial cells and directly participating in blood vessel formation, which appears in 2 distinctive forms, namely, the tubular type and the patterned matrix type. In liver cancer, VM is associated with tumor aggressiveness and poor clinical outcome. DENA-induced primary liver cancer model in rat appears an optimal VM model with both the 2 VM types. DWI and DCE-MRI were used to characterize and distinguish different VM types, and sensitively predicting diverse therapeutic responses to a vascular-disrupting agent CA4P.

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