Abstract #2783

Multiparametric MRI of a transgenic mouse model of neuroblastoma using an asymmetric high resolution 3-channel/3-animal RF coil on a clinical 3T platform

Gilberto S Almeida¹, Rafal Panek^1,2, Albert Hallsworth³, Hannah Webber³, Efthymia Papaevangelou¹, Jessica KR Boult¹, Yann Jamin¹, Louis Chesler³, and Simon P Robinson¹

¹Radiotherapy and Imaging, The Institute of Cancer Research, London, United Kingdom, ²The Institute of Cancer Research/ Royal Marsden NHS Foundation Trust, London, United Kingdom, ³Cancer Therapeutics and Clinical Studies, The Institute of Cancer Research, London, United Kingdom

The use of clinical MRI scanners to conduct preclinical research facilitates a more direct or matched comparison with clinical studies. The increased use of orthotopic and transgenic mouse tumour models in cancer research demands non-invasive methods to accurately assess their progression and treatment response in vivo. The purpose of this study was to evaluate the utility and sensitivity of anatomical and functional MRI data/biomarkers acquired from transgenic mouse models of neuroblastoma using a non-bespoke asymmetric high resolution RF coil on a clinical 3T scanner.

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