Abstract #2790

Investigation of the mouse colon wall using endoscopic MRI and confocal endomicroscopy

Hugo Dorez¹, Raphaël Sablong¹, Laurence Canaple², Sophie Gaillard¹, Hervé Saint-Jalmes^3,4, Driffa Moussata⁵, and Olivier Beuf¹

¹CREATIS, Université de Lyon ; CNRS UMR5220 ; Inserm U1044 ; INSA-Lyon ; Université Claude Bernard Lyon 1, Villeurbanne, France, ²IGFL, ENS Lyon, Lyon, France, ³LTSI - Inserm U642, Rennes, France, ⁴CRLCC, Rennes, France, ⁵Hôpital Régional Universitaire de Tours, Tours, France

The purpose of this project is to provide new tools and protocols to evaluate digestive pathologies. To this end, endoscopic MRI, using endoluminal coils, was combined with confocal endomicroscopy (CEM). Both modalities provide complementary information. CEM is well suited to investigate the surface of the colon wall whereas endoscopic MRI can assess deeper structures. It allows characterizing and staging the first steps of cancer development. The study was performed on a mouse model of colitis following 24 animals. This opens perspectives to better understand digestive pathologies such as colorectal cancer and inflammatory bowel disease.

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