Abstract #2793

Effect of Neoadjuvant Chemotherapy on in-vivo MRS determined tCho and Membranous and Cytoplasmic b-catenin Expression in Breast Cancer Patients

Naranamangalam R Jagannathan¹, Khushbu Agarwal¹, Uma Sharma¹, Sandeep Mathur², Vurthaluru Seenu³, and Rajinder Parshad³

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Pathology, All India Institute of Medical Sciences, New Delhi, India, ³Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India

We evaluated the changes in tCho levels and β-catenin expression (membrane and cytoplasm) after III neoadjuvant chemotherapy in breast cancer patients. Significant reduction in β-catenin expression (membranous and cytoplasmic) was observed after therapy. Post-therapy, tCho reduced significantly in tumors with Grades 1 and 2 membranous β-catenin expression and also in tumors with IRS 0 and Grade 1 cytoplasmic β-catenin. Prior to therapy, tCho was positively associated with cytoplasmic β-catenin while negatively with membranous protein. However post-therapy tCho was negatively associated with both cytoplasmic and membranous β-catenin. This signifies antiproliferative and apoptosis induction effects of chemotherapy drugs on breast cancer patients.

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