Early Assessment of Antiangiogenic Effects of Sorafenib using IVIM in Mouse Model with Hepatocellular Carcinoma
Yong Zhang1, Bing Wu1, Xin Chen2, and Zaiyi Liu2
1GE Healthcare MR Research China, Beijing, China, People's Republic of, 2Radiology, Guangdong General Hospital, Guangzhou, China, People's Republic of
Antiangiogenic
therapy is efficient to treat hypervascular tumor such as hepatocelluar
carcinoma (HCC). Unlike chemotherapy and radiation therapy, tumor dimension doesn’t
change in its early phase. Hence traditional reponse criteria based on
morphological change fails to early assess the therapeutic response of
antiangiogenic treatment. This study used intravoxel incoherent motion (IVIM) theory
to separate perfusion and diffusion characteristics in HCC over sereval time points after antiangiogenic Sorafenib administration. It
was found that IVIM-derived pure diffusivity and pseudo-diffusivity were able to
detect the microvascular collapse and cellular edema in HCC at early phase of
antiangiogenic medication.
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