Monitoring Breast Cancer Response to Neoadjuvant Chemotherapy by Diffusion Tensor Imaging
Edna Furman-Haran1, Noam Nissan2, Hadassa Degani2, and Julia Camps Herrero3
1Department of Biological Services, The Weizmann Institute of Science, Rehovot, Israel, 2Department of Biological Regulation, The Weizmann Institute of Science, Rehovot, Israel, 3Radiology, Hospital de la Ribera, Alzira, Spain
We have
evaluated the ability of diffusion tensor imaging (DTI) to assess
breast cancer response to neoadjuvant chemotherapy. Changes in lesion size and
diffusion parameters in response to therapy were determined. Diameter and
volume measurement derived from DTI were compared
to those derived from dynamic contrast enhanced (DCE) MRI and to
post surgery pathological reports. A high congruence was found between DTI and
DCE-MRI for tumor size and response evaluation, with both methods showing a
good agreement with pathology results.
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