Monitoring Changes of the Tumor Microenvironment Following Administration of a Novel Vascular Disrupting Agent OXi6197 Using Multi-parametric MRI
Heling Zhou1, James Campbell1, Zhang Zhang2, Debabrata Saha2, Rebecca Denney1, Mary Lynn Trawick3, Kevin G Pinney3, and Ralph P Mason1
1Radiology, UT Southwestern Medical Center, Dallas, TX, United States, 2Radiation Oncology, UT Southwestern Medical Center, Dallas, TX, United States, 3Chemistry and Biochemistry, Baylor University, Waco, TX, United States
Vascular
disrupting agents (VDAs), selectively damage the endothelial cells of tumor
blood vessels, inducing ischemia and consequent hypoxia and cell death. We
investigated the impact of a novel indole-based VDA (OXi6197) to tumor
perfusion and oxygenation using multi-parametric MRI on a lung tumor animal
model. DCE MRI showed decreased blood flow after administration of VDA. Oxygen
sensitive MRI, BOLD and TOLD, showed progression of hypoxia at 24 hours. Multimodality imaging provides useful
information to evaluate the efficacy of VDA. The findings in this study will be
important for dose optimization and potential combination therapy in the
future.
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