1Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India, 2Healthcare, Philips India ltd, Bangalore, India, 3Department of Neurology, KG Medical University, Lucknow, India, 4Healthcare, Philips India ltd, Gurgaon, India
Gadolinium based contrast
agents are necessary for MRI for disease detection and therapy. Studies
reported gadolinium remains in brain for long time after injecting contrast
particularly in follow up patients undergoing serial contrast applications. T1
signal intensity increases slowly due to contrast accumulation in brain. Our
study quantifies T1 relaxation time as a measure for follow up contrast
patients. Results show absolute T1 significantly decreases in Gray Matter
regions, putamen, thalamus and globus pallidus. We conclude that absolute T1
quantification can efficiently pick up deposition of gadolinium much earlier
than T1 signal intensity changes as observed in Gray matter regions.
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