Abstract #2824

Quantitative T2 mapping using a modified BIR-4 T2 preparation in the presence of large B0 offsets

Dominik Weidlich¹, Hendrik Kooijman², Peter Börnert³, Jan S. Kirschke⁴, Ernst J. Rummeny¹, Axel Haase⁵, and Dimitrios C. Karampinos¹

¹Department of Diagnostic and Interventional Radiology, Technische Universität München, Munich, Germany, ²Philips Healthcare, Hamburg, Germany, ³Philips Research Laboratory, Hamburg, Germany, ⁴Section of Neuroradiology, Technische Universität München, Munich, Germany, ⁵Zentralinstitut für Medizintechnik, Technische Universität München, Garching, Germany

T2 mapping has been emerging as a tool to quantitatively assess tissue edema and inflammation. Sequences employing T2 preparation have been suggested for accurate and precise T2 quantification. The use of the modified BIR-4 pulse has been proposed to minimize the sensitivity of T2 mapping to B1 inhomogeneities. However, in the presence of large B0 offsets, part of the magnetization can experience both T1 and T2 relaxation during the BIR-4 pulse leading to T2 quantification errors. The present work proposes a novel methodology to make T2 quantification based on the modified BIR-4 robust to the presence of large B0 offsets.

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