Abstract #2827

T1ρ dispersion in human calf muscle

Ping Wang^1,2, Henry Zhu^1,2, Hakmook Kang³, Jake Block², and John C. Gore^1,2

¹Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States, ²Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States, ³Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States

T_1ρ imaging is sensitive to slow macromolecular interactions which may be generally characterized by a correlation time (τ_c) but also varies with the strength of the locking field used (ω₁). At higher fields (3T and beyond) T_1ρ is also strongly influenced by chemical exchange processes and the dispersion of the relaxation rate R_1ρ (=1/T_1ρ) with locking field may be used to quantify exchange processes. We imaged normal muscles from individuals of different ages and found that R_1ρ value is negatively correlated with age in normal muscle, and there is a small dispersion of R_1ρ that appears to increase with age.

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