The longitudinal relaxation time in the rotating frame (T1ρ) is a non-invasive biomarker, which is sensitive to slow macromolecular interactions. It might potentially be useful to detect pathological changes in neurodegenerative diseases such as Alzheimer’sDisease. However, long scan times and high SAR limit the application of this technique in a routine setting. Furthermore, high CSF signal modulates the image intensity at CSF/tissue boundaries leading to an overestimation of T1ρ in these regions. To overcome these issues we developed a fast and robust approach to assess T1ρ in the human brain at high image resolution.