Huanling Liu1,2, Wenbo Li1,3, Yuguo Li1,3, Dexiang Liu1,2, Hanwei Chen2,3, Peter C.M Van Zijl1,3, and Guanshu Liu1,3
1F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, 2Department of Radiology, Guangzhou Panyu Central Hospital, Guangzhou, China, People's Republic of, 3The Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Johns Hopkins University School of Medicine, Baltimore, MD, United States
There is an urgent need for a quantitative
imaging technique that can stage deep vein thrombosis (DVT) and guide thrombolysis
treatment. In the present study, we explored
the ability of quantitative Magnetization transfer (qMT) technique as a
non-invasive means to stage thrombi based on their macromolecular content. Thrombi
in the inferior vena cava were formed using a Mouse Complete Stasis Model.
A two-pool MT mathematical model was adapted to fit high-resolution MT data of excised
thrombi samples. The results clearly showed that bound proton fraction (BPF) is
a useful parameter for distinguishing aged blood clots from freshly formed ones.