Abstract #2902

Tissue Characterization with Fast High Resolution Magic Angle Spinning (HRMAS) CEST Spectroscopy

Iris Yuwen Zhou¹, Taylor Fuss^1,2, Gang Xiao³, Takahiro Igarashi¹, Lin Li¹, Leo L. Cheng^1,2, and Phillip Zhe Sun¹

¹Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States, ²Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, ³Department of Mathematics and Statistics, Hanshan Normal University, Chaozhou, China, People's Republic of

Z-spectrum is conventionally acquired through multiple experiments with selective saturation at different frequency offsets of interest, leading to extreme long acquisition time. Here, we employ gradient-encoding to substantially accelerate the acquisition of Z-spectrum. This speedup in combination with higher spectral resolution provided by high resolution magic angle spinning (HRMAS) allows rapid quantification of chemical exchange rates of CEST agents, monitoring dynamic processes and fast tissue characterization. The approach was validated in phantom and used for characterization of brain tissues after ischemic stroke.

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