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Abstract #2929

Improved fitting of 129Xe spectroscopy identifies three dissolved-phase resonances in the human lung

Scott H. Robertson1,2, Elianna A. Bier1,2, Rohan S. Virgincar1,3, and Bastiaan Driehuys1,2,3,4

1Center for In Vivo Microscopy, Duke University Medical Center, Durham, NC, United States, 2Medical Physics Graduate Program, Duke University, Durham, NC, United States, 3Department of Biomedical Engineering, Duke University, Durham, NC, United States, 4Department of Radiology, Duke University Medical Center, Durham, NC, United States

Hyperpolarized 129Xe experiences chemical shifts between the lung airspaces, interstitium, and capillary beds, enabling functional information to be directly probed. However, in order to realize the potential of these chemical shifts, the spectrum must be carefully decomposed. Previous methods have assumed only two dissolved-phase resonances exist in the human lung and have used inconsistent 0 ppm reference frequencies. Here we present novel non-linear fitting of complex exponentially decaying FIDs and demonstrate that the dissolved phase signal can be robustly decomposed into three dissolved-phase resonances. We present updated frequencies and widths using and appropriately adjusted 0 ppm reference value.

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