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Abstract #2947

Liver IVIM MR imaging: improved reproducibility of pseudo-diffusion coefficient D* via proper signal modeling

Shih-Han Hung1, Meng-Chieh Liao1, Cheng-Ping Chien1, Wen-Chau Wu2, and Hsiao-Wen Chung3

1Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, 2Graduate Institute of Oncology, National Taiwan University, Taipei, Taiwan, 3Electrical Engineering, National Taiwan University, Taipei, Taiwan

A new scheme was proposed to analyze intravoxel ihcoherent motion MR imaging data of the liver. The method integrated the combined use of single- and bi-exponential signal decaying models to deal with regions with absence of prominent vasculature, and the removal of data obtained at b-values less than 15s/mm2 to avoid contamination from large vessels. Results from ten healthy subjects scanned twice at 3T showed substantially improved reproducibility in the pseudo-diffusion coefficient D*, while those of the true diffusion coefficient and the profusion fraction were unaltered. Using our scheme the estimated D* mostly fall within 38 to 85x10-3 mm2/s.

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