Elizabeth Li1, Tim Lu1, Alexandre Coimbra1, and Alex de Crespigny 1
mapping may provide estimates of extent of fibrosis in Crohn’s Disease (CD)
patients but are subject to respiratory and peristaltic motion. Various image
registration strategies and their impact on quality and robustness of parametric
maps of gain of enhancement (GE) and magnetization transfer ratio (MTR) were
compared. Healthy test-retest and CD image datasets were evaluated. Spatial
registration improved quality and test-retest reliability of GE and MTR maps.
In a limited cohort, extent of fibrosis estimated with GE and MTR maps were correlated. Cross validation of MR enterography-based fibrosis estimates with
histological data will be conducted as data becomes available.