Abstract #2988

High Resolution Blood Vessel Imaging with USPIOs in the Human Brain: T1 vs T2* contrast.

Thomas Christen¹, Samantha Holdsworth¹, Samuel Cheshier², Michael Moseley¹, Greg Zaharchuk¹, and Kristen Yeom¹

¹Radiology, Stanford University, Palo Alto, CA, United States, ²Neurosurgery, Stanford University, Stanford, CA, United States

In this study, we probed the potential of ultrasmall superparamagnetic iron oxide particles (USPIOs) to provide high-resolution angiographic images of the human brain using T2* and T1 contrasts. 10 paediatric patients suspected of arteriovenous malformations (AVM) were scanned pre and post intravenous USPIOs injection as part of their clinical exam. To test the influence of USPIOs concentration on both T2* and T1 images, a healthy volunteer was scanned before and after injections of 7 incremental doses of the contrast agent. The results suggest that both approaches can provide exquisite details of the neurovascular anatomy while offering complementary information.

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