Andrada Ianuș1, Ivana Drobnjak1, Noam Shemesh2, and Daniel C. Alexander1
1CMIC, University College London, London, United Kingdom, 2Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal
In
the long mixing time regime, double-diffusion-encoding (DDE)
sequences provide contrast capable of reflecting microscopic
anisotropy, which may have added value for highly heterogeneous
tissues such as the gray matter. Recently, double-oscillating-diffusion-encoding (DODE) sequences, which combine oscillating
waveforms and varying gradient orientation, have been proposed
to improve sensitivity to microscopic anisotropy. This work
investigates the effect of varying different sequence parameters and shows that DODE sequences provide higher sensitivity to pore size for elongated pores, while DDE sequences are more sensitive to pore eccentricity.
