Abstract #3018

A new framework for the optimisation of multi-shell diffusion weighting MRI settings using a parameterised Cramér-Rao lower-bound

Ezequiel Farrher¹, Ivan I. Maximov², Vincent Gras¹, Farida Grinberg^1,3, Rüdiger Stirnberg^1,4, and N. Jon Shah^1,3

¹INM 4 - Medical Imaging Physics, Forschungszentrum Jülich, Jülich, Germany, ²Experimental Physics III, TU Dortmund University, Dortmund, Germany, ³Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, ⁴German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany

We propose a parameterisation for multi-shell diffusion gradient settings which is sufficiently flexible to cover a broad range of experimental configurations, on the one hand, but uses only 6 degrees of freedom, on the other. Thus, such parameterisation enables a robust optimisation of the diffusion weighting settings by minimising the Cramér-Rao lower bound of the parameters of interest. Finally, we demonstrate its performance in the context of the biexponential diffusion tensor analysis.

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