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Abstract #3046

Emerging applications of intravoxel incoherent motion MRI in primary nasopharyngeal carcinoma

Shuixing Zhang1, Long Liang1, Bin Zhang1, Barbara Dong1, Kannie W.Y. Chan2, Guanshu Liu2, and Changhong Liang1

1Department of Radiology, Guangdong Academy of Medical Sciences/Guangdong General Hospital, Guangzhou, Guangdong Province, China, Guangzhou, China, People's Republic of, 2Russell H. Morgan Department of Radiology and Radiological Sciences, Division of MR Research, The Johns Hopkins University School of Medicine, Baltimore 21287, USA, Baltimore, AL, United States

Worldwide, nasopharyngeal carcinoma (NPC) is a rare malignancy, but it shows marked geographic and racial variation in incidence and is particularly endemic in southern China. The aim of our study is to compare pure molecular diffusion (D), perfusion-related diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) based on intravoxel incoherent motion (IVIM) theory in patients with NPC. Our results revealed that IVIM DWI is a feasible technique for investigating primary NPC. D was significantly decreased in primary NPC, and increased D* reflected increased blood vessel generation and parenchymal perfusion in primary NPC.

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Abstract