Mark David Meadowcroft1,2, Timothy Cooper3, Michele Ferenci2, Elizabeth B Neely1, Ephraim Church1, Thaddeus Wright1, Sebastian Rupprecht2, Weimin kang1, Jenelle Tretter3, Qing X Yang2, Robert E Harbaugh1, James R Connor1, and James Mcinerney1
1Neurosurgery, The Pennsylvania State University - College of Medicine, Hershey, PA, United States, 2Radiology, The Pennsylvania State University - College of Medicine, Hershey, PA, United States, 3Comparative Medicine, The Pennsylvania State University - College of Medicine, Hershey, PA, United States
Current treatment options for un-ruptured intracranial aneurysms
typically include open clipping, endovascular embolization, or observation. We
undertook this study to examine the effects of GKRS on an in vivo rabbit aneurysm model.
Involution of aneurysms after GKRS could provide a safer and more
cost-effective treatment alternative for patients harboring un-ruptured
intracranial aneurysms. The results of
the study reveal a 40 percent reduction in aneurysm total volume, internal
volume, and surface area over the 24-month period. Targeted GKRS is successful in promoting
histological and hemodynamic changes to the rabbit carotid aneurysm, linearly
reducing size over time.