Exercise stress cardiac MR assessment of diastolic function in healthy volunteers and pulmonary hypertension
Thomas Kennedy1, Omid Forouzan2, Oliver Wieben1,3, Naomi C Chesler2, Jacob Macdonald3, and Christopher J Francois1
1Radiology, University of Wisconsin- Madison, Madison, WI, United States, 2Biomedical Engineering, University of Wisconsin- Madison, Madison, WI, United States, 3Medical Physics, University of Wisconsin- Madison, Madison, WI, United States
Dyspnea on exertion is a
common manifestation of systolic and diastolic heart failure. Using an
MRI-compatible exercise device allowing subjects to exercise while in the bore
of the scanner, we assessed exercise-induced changes in diastolic transmitral
flow in younger and older healthy volunteers and subjects with pulmonary
hypertension. The measurements we obtained demonstrated decreased E/A ratios
for older healthy volunteers and PH subjects when compared to younger healthy
volunteers, however these differences were not statistically significant.
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