A Computational Fluid Dynamics Simulation Study on the Influence of the Tortuosity of the Coronary Arteries on Contrast Agent Bolus Dispersion in Contrast-Enhanced Myocardial Perfusion MRI
Regine Schmidt1, Hanns-Christian Breit1, and Laura Maria Schreiber1,2
1Section of Medical Physics, Department of Radiology, Johannes Gutenberg University Medical Center, Mainz, Germany, 2Department of Cellular and Molecular Imaging, Comprehensive Heart Failure Center (CHFC), Wuerzburg, Germany
The dispersion of
the contrast agent bolus at T1-weighted contrast-enhanced first-pass myocardial
perfusion MRI was examined by means of computational fluid dynamics
simulations. In this study simulations in idealized coronary artery geometries with
different extent of vessel tortuosity and in a straight reference vessel
geometry have been performed for the condition of rest and stress. The contrast
agent bolus dispersion was larger at rest compared to stress. Furthermore, a
negative correlation between the extent of tortuosity and the contrast agent
bolus dispersion was found.
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