Abstract #3152

Myocardial T1- and ECV- Mapping at 3 Tesla using the Saturation-Recovery Techniques SASHA and SAPPHIRE

Nadja M Meßner^1,2, Sebastian Weingärtner^1,3,4, Johannes Budjan⁵, Dirk Loßnitzer⁶, Uwe Mattler⁵, Theano Papavassiliu^2,6, Lothar R Schad¹, and Frank G Zöllner¹

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, Germany, ³Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, MN, United States, ⁴Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, ⁵Institute of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁶1st Department of Medicine Cardiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

Myocardial T₁- and ECV-mapping for the detection of fibrosis is commonly performed at 1.5T with inversion-recovery (IR) techniques such as MOLLI.

As an alternative, we studied the robustness and precision of the saturation-recovery (SR) T₁-mapping techniques SAPPHIRE and SASHA at 3T in 20 healthy volunteers. The resulting T₁- and ECV- reference values for SR T₁-mapping were 1578±42ms/0.30±0.03 (SAPPHIRE) and 1523±46ms/0.31±0.03 (SASHA), revealing the underestimation of T₁-times by MOLLI to be approximately 20-29%.

Therefore, we suggest SR T₁-mapping with its high accuracy, low precision-loss, and good inter-subject variability as a valuable alternative to IR T₁-mapping at 3T.

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