Sensitive Non-contrast CMR Index for Quantifying Myocardial Fibrosis
Jiayu Sun1, Simeng Wang1, Robert O'Connor2, David Muccigrosso3, Yucheng Chen4, Wei Cheng1, Charles Hildebolt3, Fabao Gao1, and Jie Zheng3
1Radiology, West Hospital, Chengdu, China, People's Republic of, 2NIH, Bethesda, MD, United States, 3Radiology, Washington University in St. Louis, St. Louis, MO, United States, 4Cardiology, West Hospital, Chengdu, China, People's Republic of
The purpose is to develop and evaluate a non-contrast CMR approach for sensitive and
quantitative assessment of myocardial fibrosis. Ten patients with
cardiomyopathy were scanned with and without contrast injection. A quantitative
fibrosis index derived from native T1ρ dispersion contrast was obtained and compared
with extracellular volume calculated by T1 mapping. A strong correlation was
shown between two indexes and superior sensitivity was observed for fibrosis index to
detect myocardial diffuse fibrosis.
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