Abstract #3161

Myocardial Effective Transverse Relaxation Time at 7.0 T Correlates with Left Ventricular Wall Thickness

Till Huelnhagen¹, Teresa Serradas Duarte¹, Fabian Hezel¹, Erdmann Seeliger², Bert Flemming², Marcel Prothmann³, Jeanette Schulz-Menger³, and Thoralf Niendorf^1,4

¹Berlin Ultrahigh Field Facility (B.U.F.F), Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany, ²Institute for Physiology, Charité University Medicine, Berlin, Germany, ³Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, ⁴Experimental and Clinical Research Center, a joint cooperation between the Charité Medical Faculty and the Max Delbrück Center for Molecular Medicince in the Helmholtz Association, Berlin, Germany

This work examines the relationship of ventricular septal wall thickness and T₂* at 7.0T in healthy volunteers. Results show, that T₂^* changes periodically over the cardiac cycle, increasing in systole and decreasing in diastole. A strong correlation between mean septal T₂^* and wall thickness was found. Temporally resolved field mapping showed that macroscopic magnetic field fluctuations can be excluded as source of the observed changes. While T₂^* is often regarded as surrogate for tissue oxygenation, the found systolic increase of T₂^* cannot be explained by increased oxygenation. Instead changes in blood volume fraction are assumed to be responsible for the observed T₂^* fluctuations.

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