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Abstract #3172

Frequency Shift Imaging (FSI) for characterization of cells labeled with superparamagnetic iron-oxide nanoparticles

Judy Alper1,2, Priti Balchandani1, Francois Fay1, and Hadrien Dyvorne1

1Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Department of Biomedical Engineering, City College of New York, New York, NY, United States

MRI has long been used as a detection tool for cells labeled with superparamagnetic iron-oxide nanoparticles (SPIOs). Positive contrast imaging of off-resonance SPIO signal provides benefits over negative contrast methods and imaging the SPIOs at 7 Tesla (7T) allows for leveraging greater off-resonance sensitivity for quantitative imaging of smaller cell populations. In this study, we imaged a cell phantom containing SPIO labeled macrophages at 7T. We demonstrated the performance of frequency shift imaging (FSI), a new acquisition technique, for characterizing the magnetic signature of SPIOs, as compared to negative contrast methods.

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