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Abstract #3178

Spectrally selective 3D dynamic bSSFP for hyperpolarized C-13 metabolic imaging at 14.1T

Hong Shang1,2, Subramaniam Sukumar1, Robert A. Bok1, Irene Marco-Rius1, Cornelius von Morze1, Adam B. Kerr3, Galen Reed4, Michael Ohliger1, John Kurhanewicz1, Peder E. Z. Larson1, John M. Pauly3, and Daniel B. Vigneron1

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2Bioengineering, UC Berkeley - UCSF, San Francisco / Berkeley, CA, United States, 3Electrical Engineering, Stanford University, Stanford, CA, United States, 4HeartVista, Menlo Park, CA, United States

Balanced SSFP sequences can provide superior SNR efficiency for hyperpolarized 13C imaging, by efficiently utilizing the non-recoverable magnetization. A spectrally selective bSSFP sequence was developed to enable fast mapping of hyperpolarized metabolites. A novel approach for bSSFP spectral selectivity was developed utilizing a combination of optimized multiband RF pulses and a bSSFP pulse train with a carefully chosen TR to avoid banding artifact. The sequence enabled 3D dynamic imaging of HP resonances generated in studies with co-polarized pyruvate and urea (with ~1% selectivity), attaining 2mm isotropic resolution and <1s temporal resolution.

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