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Abstract #3309

A DOUBLE ACQUISITION FOUR-CONTRAST IMAGING APPROACH TO DELINEATE HUMAN BRAINSTEM ANATOMY IN-VIVO AT 7 TESLA

Michael Wyss1, Laetitia Vionnet1, Mike Bruegger1,2, Bernd Daeubler3, Lars Kasper1,4, Daniel Nanz5, Marco Piccirelli3, David O. Brunner1, and Klaas P. Pruessmann1

1Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland, 2Center of Dental Medicine, University of Zurich, Zurich, Switzerland, 3Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, 4Translational Neuromodeling Unit, Institute for Biomedical Engineering, University of Zurich and ETH Zurich, Zurich, Switzerland, 5Institute of Diagnostic and Interventional Radiology, University Hospital Zurich and University of Zurich, Zurich, Switzerland

The human brainstem anatomy is challenging to image in vivo on a single subject basis. The densely-packed interspersion of nuclei and white matter tracts cannot typically be imaged with an image contrast strong enough for differentiation of relevant substructures. We present an MR imaging approach at 7 Tesla that requires two high resolution MR acquisitions. From the two data sets, four image series with varying contrast weightings can be derived and used to delineate brainstem anatomy. The proposed strategy resulted in exceptionally high image quality enabling differentiation of several brainstem substructures that are hardly discernible in commonly acquired MR images.

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