Motor Learning Induced Neuroplasticity, Revealed By fMRI-Guided Diffusion Imaging
Lee Bremner Reid1, Martin V Sale2, Ross Cunnington2,3, and Stephen E Rose1
1e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, Australia, 2Queensland Brain Institute, The University of Queensland, Brisbane, Australia, 3School of Psychology, The University of Queensland, Brisbane, Australia
requires highly sensitive measurements that may be outside the bounds of
standard parcellation-seeded tractography. Earlier attempts to measure
neuroplasticity induced by motor learning have utilised voxelwise analyses.
Such analyses are reliant on precise registration, can have low statistical
power, and provide little certainty as to the functional relevance of areas of
detected change. We have measured motor-learning-induced neuroplasticity along
corticomotor and thalamocortical tracts using fMRI-seeded diffusion-MRI, finding
that changes uniquely occur in the corticomotor tract. Unlike previous
analyses, we reveal that these changes occur throughout the corticomotor tract,
not just near the grey-/white-matter interface.
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