Abstract #3322

Insula Cortex Parcellation with Q-ball Residual Bootstrap Tractography Algorithm

Maria Luisa Mandelli¹, Matteo Paoletti², Nico Papinutto³, Bagrat Amirbekian^3,4, Roland G Henry^3,4,5, Eduardo Caverzasi^3,6, and Maria Luisa Gorno-Tempini¹

¹Neurology, Memory Aging Center, UCSF, San Francisco, CA, United States, ²Radiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy, ³Neurology, UCSF, San Francisco, CA, United States, ⁴Bioengineering Graduate Group, Berkeley, CA, United States, ⁵Radiology and Biomedical Imaging, San Francisco, CA, United States, ⁶Brain and Behavioral Sciences, Pavia, Italy

The insula cortex is involved in different functions, however its cortical connections have not yet been extensively explored. Whole brain tractography with Q-ball residual bootstrap algorithm was performed in 17 controls. Insula and the cortex regions were used as ending-ROIs. We found structural connections between the insula and 22 cortical regions for each hemisphere. After registered the images to the MNI space, the parcellation of the insula was obtained based on the ending-tract connected with each of the cortex region. Availability of a template atlas of insular structural connectivity would contribute to a better understanding of its multiple functions.

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