Abstract #3327

Regional variation of total sodium concentration in the healthy human brain

Ferran Prados^1,2, Bhavana S Solanky², Patricia Alves Da Mota², Manuel Jorge Cardoso¹, Wallace J Brownlee², Frank Riemer³, David H Miller², Xavier Golay⁴, Sebastien Ourselin¹, and Claudia Angela Michela Gandini Wheeler-Kingshott^2,5

¹Translational Imaging Group, Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ²NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom, ³Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ⁴Brain Repair & Rehabilitation, UCL Institute of Neurology, University College London, London, United Kingdom, ⁵Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy

Non-invasive measurement of in vivo total sodium concentration (TSC) has been possible due to advances in sodium MRI at clinical field strengths. Changes in white and grey matter concentrations have been reported in a number of different diseases like Multiple Sclerosis. However, the presence of regional differences in normal healthy brain TSC has not been yet investigated. Here we use Geodesic Information Flow technique for computing per subject brain parcellations to allow differentiation of these areas and subsequently characterization of regional TSC in healthy controls.

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