Jeroen C.W. Siero1, Jeroen H.J. de Bresser1, Lisa van der Kleij1, Jill B. de Vis1, and Jeroen Hendrikse1
we investigate brain volume changes upon a vasodilatory hypercapnic stimulus as
a potential alternative to obtain cerebral tissue reactivity information. Using relatively standard 3D T1-weighted scans (MP-RAGE) and segmentation
software we show significant volume changes (in all subjects) in subcortical deep
gray matter areas which were paralleled by decreases in ventricular volume.
This approach (volume reactivity) could yield novel insights on cerebral tissue
reactivity in healthy and disease and be a potential alternative in cases where
BOLD or ASL CVR interpretation can be ambiguous.